4. NK/T Cell Lymphoma

NKT Cell Responses to B Cell Lymphoma

Natural killer T (NKT) cells are a unique subset of CD1d-restricted T lymphocytes that express characteristics of both T cells and natural killer cells. NKT cells mediate tumor immune-surveillance; however, NKT cells are numerically reduced and functionally impaired in lymphoma patients. Many hematologic malignancies express CD1d molecules and co-stimulatory proteins needed to induce anti-tumor...

Activation and Exacerbates NKT Cell 4-1BB Engagement Costimulates NKT Cell

Ligand-Induced Airway Hyperresponsiveness Activation and Exacerbates NKT Cell 4-1BB Engagement Costimulates NKT Cell

NKT cell-targeted vaccination plus anti-4–1BB antibody generates persistent CD8 T cell immunity against B cell lymphoma

Harnessing the immune adjuvant properties of natural killer T (NKT) cells is an effective strategy to generate anticancer immunity. The objective of this study was to increase the potency and durability of vaccine-induced immunity against B cell lymphoma by combining α-galactosylceramide (α-GalCer)-loaded tumor cell vaccination with an agonistic antibody targeting the immune checkpoint molecule...

NKT cell–derived interferon-γ, interleukin (IL)-4, and IL-21 cytokines; and NKT cell–derived perforin and granzyme B cytotoxins in promoting CD4+ NKT cell atherogenicity

Circulation Research is available at http://circres.ahajournals.org DOI: 10.1161/CIRCRESAHA.116.304734 Rationale: CD4+ natural killer T (NKT) cells augment atherosclerosis in apolipoprotein E–deficient (ApoE)−/− mice but their mechanisms of action are unknown. Objectives: We investigated the roles of bystander T, B, and NK cells; NKT cell–derived interferon-γ, interleukin (IL)-4, and IL-21 cyto...